Bioinformatic Is Cool, I Mean Really Cool

I’ve been fascinated by genomic research for years.  While successfully implementing a fairly large and diverse set of algorithms (segmentation, image processing and machine learning) on text, image and other semi-structured datasets, till recently I didn’t have much exposure to the exciting field of bioinformatics, processing DNA and RNA sequences.

After completing Bioinformatics Methods I  and Bioinformatics Methods II (thank you Professor Nicholas Provart, University of Toronto) I have a better appreciation of the important roles of Bioinformatics in medicinal sciences and in drug discovery, diagnosis and disease management, but also a better appreciation of the complexity involved with the processing of large biological datasets.


Topics covered in these two courses include multiple sequence alignments, phylogenetics, gene expression data analysis, and protein interaction networks, in two separate parts. The first part, Bioinformatic Methods I, dealt with databases, Blast, multiple sequence alignments, phylogenetics, selection analysis and metagenomics. The second part, Bioinformatic Methods II, dealt with motif searching, protein-protein interactions, structural bioinformatics, gene expression data analysis, and cis-element predictions.

Please find below a short list of tools and resources I’ve used while completing the different labs:

NCBI/Blast I

Multiple Sequence Alignments (download tool)


Selection Analysis                 



Protein Domain, Motif and Profile Analysis       

Protein-protein interactions          (download tool)             

Structural Bioinformatics (download tool)            

Gene Expression Analysis

Gene Expression Data Analysis

Cis regulatory element mapping and prediction

Additional Coursers Computational Molecular Evolution Bioinformatics Python Web Applications (Ruby on Rails) Epigenetics Genomic & Precision Medicine Useful Genetics


Zvelebil & Baum 2008 Understanding Bioinformatics. Garland Science, New York

Understanding Bioinformatics

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s